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1 edition of The role of apoptosis in sarcopenia found in the catalog.

The role of apoptosis in sarcopenia

the effects of age and caloric restriction on skeletal muscle apoptosis

by Amie J. Dirks

  • 355 Want to read
  • 14 Currently reading

Published .
Written in English


Edition Notes

Statementby Amie J. Dirks
The Physical Object
Paginationviii, 88 leaves :
Number of Pages88
ID Numbers
Open LibraryOL25933080M
OCLC/WorldCa50511810

Sarcopenia is a major therapeutic challenge and a public health priority in both the US and Europe. More than two decades after the word was first used to define a distinct clinical condition, the definition of sarcopenia remains open for discussion,nd its clinical relevance is still not fully understood. This book provides some answers. It is a valuable addition to the existing 5/5(1). This book provides the latest information on sarcopenia from leading international researchers studying the cellular and molecular mechanisms underlying age-related changes in skeletal muscle and identifies strategies to combat sarcopenia and related muscle wasting conditions and neuromuscular disorders.5/5(1).

Primary sarcopenia is considered to be age-related when no other cause is evident, other than aging itself. Secondary sarcopenia should be considered when one or more other causes are evident, such as multiple chronic conditions. Previous studies have reported that low muscle strength and impaired physical performance can be found in chronic diseases, including Author: Raoul Saggini, Simona Maria Carmignano, Lucia Cosenza, TommasoPalermo, Rosa Grazia Bellomo. If apoptosis does indeed play a role in sarcopenia, then research directed towards decreasing DNA fragmentation and caspases and promoting anti-apoptotic protein expression in aged skeletal muscle is warranted. j. Telomere shortening: With aging there is cellular senescence in multiple organs.

Apoptosis is an important process that occurs in multicellular organisms, both during normal development and for maintain-ing tissue homeostasis. 13 However, the role of apoptosis in post-mitotic tissues, such as skeletal muscle, has not been clarifi ed. The initial stage of apoptosis involves the induction of. king Group on Sarcopenia in Older People (EWGSOP, the Sarcopenia Working Group) proposed the definition based on an algorithm based on the preliminary screening of low gait speed (threshold established at ≤ ms-1) and low handgrip strength (lowest quartile of sample distribution). [22] A clinical definition of sarcopenia ought to use methodsCited by:


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The role of apoptosis in sarcopenia by Amie J. Dirks Download PDF EPUB FB2

Abstract. Skeletal muscle atrophy and the loss of myofibers contribute to sarcopenia, a condition associated with normal aging. However, relatively little is known regarding the relevance of apoptosis to skeletal muscle homeostasis and the possible mechanisms involved, although evidence suggests that apoptosis may play a role during muscle by: Role of Apoptosis in Sarcopenia Article Literature Review in The Journals of Gerontology Series A Biological Sciences and Medical Sciences 58(11) December with ReadsAuthor: Christiaan Leeuwenburgh.

This targeted apoptosis or “nuclear apoptosis” appears to have a role in regulating aging-induced muscle loss (sarcopenia) by reducing the myofiber volume (i.e. cytoplasm) that can be supported in a single muscle fibre.

Recent investigations indicate The role of apoptosis in sarcopenia book apoptotic signaling in aged skeletal muscles occurs through three apoptotic by: 1.

Although the exact physiologic function of nuclear apoptosis in skeletal myofibers is not fully understood, the data support a role for nuclear apoptosis in mature skeletal myofibers under various muscle wasting conditions including hindlimb unweighting, muscle disuse/unloading, muscle denervation, and sarcopenia (18,20,).

The role of apoptosis in post mitotic tissues, such as skeletal muscle, is less well defined. Apoptosis during muscle atrophy occurs in both myonuclei and other muscle cell types. Apoptosis of myonuclei likely contributes to the loss of muscle mass, but the mechanisms underlying this process are largely by: Although the etiology of sarcopenia is complex and characterized by the contribution of multiple factors [43], there is growing evidence for a prominent role.

Skeletal myocyte atrophy and death contribute to sarcopenia, a condition associated with normal aging. By 80 years of age, it is estimated that humans generally lose 30–40% of skeletal muscle fibres.

The mechanism for this loss is unknown; however, it may involve apoptosis. Mitochondrial dysfunction and sarcoplasmic reticulum (SR) stress that Cited by: Accelerated apoptosis of muscle fibers may represent a key mechanism underlying sarcopenia.

Moreover, preclinical evidence also indicates a role for apoptosis in muscle atrophy subsequent to acute disuse, a model that may resemble the muscle loss observed during prolonged bed by:   The degenerative changes of the neuromuscular system may also affect directly the muscle cell itself independently of the neuropathic processes since there is increasing evidence that apoptosis of skeletal myocytes contributes to sarcopenia.

59 Mitochondrial dysfunction and sarcoplasmic reticulum stress seem to play a key role in inducing Cited by: The role of apoptosis in age-related and disuse-related muscle loss is starting to be explored, but is still uncertain. Apoptosis is very likely involved in the loss of muscle nuclei with disuse, but whether it is also responsible for the loss of actual muscle fibers with aging (sarcopenia) needs to be further by: Aging is a complex process characterized by progressive multisystem derangement predisposing individuals to increased risk of developing negative health outcomes.

Sarcopenia is the age-related decline of muscle mass and function/strength and represents a highly prevalent correlate of aging. Several factors have been indicated to play a role in the onset and progression of Cited by: Readers will find key information about the role of sex hormones in mitochondrial physiology and their relation with ageing, apoptosis, and sarcopenia.

Chapters integrate important points with the latest information on the subject, including work of leading researchers studying the cellular and molecular mechanisms underlying the age-linked Author: Andrea Vasconsuelo, Florencia Antonella Musso, Lucía Pronsato, Lorena M.

Milanesi, María Belén Farao. The book present in integrated form the latest information on sarcopenia and its relation with apoptosis, from leading researchers studying the cellular and molecular mechanisms underlying age- linked changes in skeletal muscle emphasizing on the role of satellite cells.

Sarcopenia is a major therapeutic challenge and a public health priority in both the US and Europe. More than two decades after the word was first used to define a distinct clinical condition, the definition of sarcopenia remains open for discussion,nd its clinical relevance is still not fully understood.

This book provides some answers.5/5(2). Sarcopenia is the degenerative loss of skeletal muscle mass (–1% loss per year after the age of 50), quality, and strength associated with aging. Sarcopenia is a component of the frailty is often a component of can also exist independently of cachexia; whereas cachexia includes malaise and is secondary to an underlying pathosis (such as Specialty: Geriatrics, Rheumatology.

This book provides the latest information on sarcopenia from leading international researchers studying the cellular and molecular mechanisms underlying age-related changes in skeletal muscle and identifies strategies to combat sarcopenia and related muscle wasting conditions and neuromuscular disorders.

The book present in integrated form the latest information on sarcopenia and its relation with apoptosis, from leading researchers studying the cellular and molecular mechanisms underlying age. In the body, millions of cells die and proliferate each day to maintain normal function and cooperation of all tissues, organs, and systems.

Thus, programmed cell death, or apoptosis, is critical to sustain growth, development, and body health. The vital role of B-cell leukemia/lymphoma-2 (BCL-2) family proteins in apoptosis has been : Chen Zheng, Ting Liu, Huihui Liu, Jing Wang.

This suggests that apoptosis in mutant mice is mitochondrial-mediated, and is conferred upon mitochondrial dysfunction. Thus, mutations in mtDNA play a causal role in sarcopenia, through enhancing apoptosis induced by mitochondrial dysfunction. (en) General Note: In the series University of Florida Digital Collections.

General Note: Includes. Sarcopenia, the age-related decline in muscle mass and function, represents a significant health issue due to the high prevalence of frailty and disability associated with this condition.

Nevertheless, the cellular mechanisms responsible for the loss of muscle mass in old age are still largely unknown. An altered regulation of myocyte apoptosis has recently emerged as a Cited by:.

Some of the most serious consequences of aging are its effects on skeletal muscle. ‘Sarcopenia’, the progressive age-related loss of muscle mass and associated muscle weakness, renders frail elders susceptible to serious injury from sudden falls and fractures and at risk for losing their functional independence.

Not surprisingly, sarcopenia is a significant public health problem. T1 - The role of dietary protein intake in the prevention of sarcopenia of aging.

AU - Beasley, Jeannette M. AU - Shikany, James M. AU - Thomson, Cynthia A. PY - /12/4. Y1 - /12/4. N2 - Sarcopenia is defined as an age-related decrease in Cited by: Apoptosis is an international peer-reviewed journal devoted to the rapid publication of innovative basic and clinically-oriented investigations into programmed cell death.

It aims to stimulate research on the basis of mechanisms of apoptosis and on its role in various human disease processes including: cancer, autoimmune disease, viral.